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  2. Leif D. Nelin, MD

Division Chief of Neonatology at Nationwide Children's Hospital
Dean Jeffers Endowed Chair in Neonatology
Professor of Pediatrics at Ohio State University College of Medicin

Nationwide Children's Hospital, Pediatrics
Neonatology
700 Children's Dr
Columbus, OH 43205
contact address
https://www.nationwidechildrens.org/find-a-doctor/profiles/leif-d-nelin...

Biosketch:

Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Selected Bibliography:

James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H.
Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support.
J Pediatr. 2017;190:118-123.e4. PubMed abstract / Full Text

Nelin LD, Logan JW.
The use of inhaled corticosteroids in chronically ventilated preterm infants.
Semin Fetal Neonatal Med. 2017;22(5):296-301. PubMed abstract

Shepherd EG, Nelin LD.
Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease.
Am J Respir Crit Care Med. 2017;196(3):264-265. PubMed abstract

Nelin LD, Potenziano JL.
Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response.
BMC Pediatr. 2019;19(1):17. PubMed abstract / Full Text

Nelin LD, Bhandari V.
How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and "tomorrow".
F1000Res. 2017;6:539. PubMed abstract / Full Text